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Volume 24 , Issue 2
March/April 2004
Pages 119–125

Treatment of Chronic Desquamative Gingivitis Using Tissue-Engineered Human Cultured Gingival Epithelial Sheets: A Case Report

Kazuhiro Okuda, PhD, DDS/Manabu Momose, PhD, DDS/Masashi Murata, PhD, DDS/Yoshinori Saito, PhD, DDS/Masukazu Inoie/Chikara Shinohara, PhD/Larry F. Wolff, PhD, DDS/Hiromasa Yoshie, PhD, DDS

PMID: 15119882
DOI: 10.11607/prd.00.0572

Human cultured gingival epithelial sheets were used as an autologous grafting material for regenerating gingival tissue in the maxillary left and mandibular right quadrants of a patient with chronic desquamative gingivitis. Six months postsurgery in both treated areas, there were gains in keratinized gingiva and no signs of gingival inflammation compared to presurgery. In the maxillary left quadrant, preoperative histopathologic findings revealed the epithelium was separated from the connective tissue and inflammatory cells were extensive. After grafting with the gingival epithelial sheets, inflammatory cells were decreased and separation between epithelium and connective tissue was not observed. The human cultured gingival epithelial sheets fabricated using tissue engineering technology showed significant promise for gingival augmentation in periodontal therapy. (Int J Periodontics Restorative Dent 2004;24:119–125.)

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